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Because host DNA synthesis remains unaffected, adverse effects do not include bone marrow depression. Acyclovir is eliminated unchanged in urine (t1/2 ~ 2. 5 h). Valacyclovir, the L-valyl ester of acyclovir, is a prodrug that can be administered orally in herpes zoster infections. Its absorption rate is approx. twice that of acyclovir.
A possible explanation is that both agents already interfere with elements of ADP receptor signal transduction at the megakaryocytic stage. The ensuing functional defect would then be transmitted to newly formed platelets, which would be incapable of reversing it. The intra-platelet levels of cAMP can be stabilized by prostacyclin or its analogues (e. g. , iloprost) or by dipyridamole. |
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